The X-linked gene encoding MECP2 is involved in two severe and complex
neurodevelopmental disorders. Loss of function of the MeCP2 protein underlies Rett …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …

Abstract Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET)
DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of …

To form synaptic connections and store information, neurons continuously remodel their
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …

Here we present APOBEC-coupled epigenetic sequencing (ACE-seq), a bisulfite-free
method for localizing 5-hydroxymethylcytosine (5hmC) at single-base resolution with low …

Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene
methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator …

MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …

Massively parallel single-cell RNA sequencing can precisely resolve cellular diversity in a
high-throughput manner at low cost, but unbiased isolation of intact single cells from …

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome. MeCP2 is
thought to regulate gene transcription by binding to methylated DNA broadly across the …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …