Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application
J **e, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …
been predominantly used in basic and preclinical research during the last 30 years. Since …
Cell penetrating peptides, novel vectors for gene therapy
Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …
Stromal modulation and treatment of metastatic pancreatic cancer with local intraperitoneal triple miRNA/siRNA nanotherapy
Nanomedicines achieve tumor-targeted delivery mainly through enhanced permeability and
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …
The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery
The multidisciplinary approaches in treatment of cancer appear to be essential in term of
bringing benefits of several disciplines and their coordination in tumor elimination. Because …
bringing benefits of several disciplines and their coordination in tumor elimination. Because …
Truly tiny acoustic biomolecules for ultrasound imaging and therapy
Nanotechnology offers significant advantages for medical imaging and therapy, including
enhanced contrast and precision targeting. However, integrating these benefits into …
enhanced contrast and precision targeting. However, integrating these benefits into …
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and
drug resistance due, in part, to poor drug delivery to extravascular tumor tissue. Here, we …
drug resistance due, in part, to poor drug delivery to extravascular tumor tissue. Here, we …
Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system
RNA interference (RNAi) therapeutics are an emerging class of medicines that selectively
target mRNA transcripts to silence protein production and combat disease. Despite the …
target mRNA transcripts to silence protein production and combat disease. Despite the …
Co-inhibition of the TGF-β pathway and the PD-L1 checkpoint by pH-responsive clustered nanoparticles for pancreatic cancer microenvironment regulation and anti …
Y Wang, Z Gao, X Du, S Chen, W Zhang, J Wang… - Biomaterials …, 2020 - pubs.rsc.org
Pancreatic ductal adenocarcinoma (PDAC) has a dense extracellular matrix (ECM)
surrounding tumor cells to sequester CD8+ T cell infiltration and prevent drug penetration …
surrounding tumor cells to sequester CD8+ T cell infiltration and prevent drug penetration …
Peptide-based nanoparticles for therapeutic nucleic acid delivery
Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the
immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a …
immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a …
Regulation of tumor microenvironment for pancreatic cancer therapy
Pancreatic cancer (PC) is one kind of the most lethal malignancies worldwide, owing to its
insidious symptoms, early metastases, and negative responses to current therapies. With an …
insidious symptoms, early metastases, and negative responses to current therapies. With an …