Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Neuropsychiatric symptoms (NPS) such as depression, apathy, aggression, and psychosis
are now recognized as core features of Alzheimer's disease (AD), and there is a general …

The globally increasing annual incidence of chronic obstructive pulmonary disease (COPD),
a common chronic disease, poses a serious risk to public health. Although the exact …

As a type of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, sirtuin 2
(SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system …

Depression occurs with a high prevalence of up to 50% in patients with Alzheimer's disease
(AD) and increases the caregivers' burden. Depression symptoms can precede clinical …

Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes.
Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a …

Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with
important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular …

Background and objective Chronic obstructive pulmonary disease (COPD) is a complex
chronic inflammatory disease of the respiratory system affecting primarily distal respiratory …

Background Major depression (MD) is the most prevalent psychiatric disease in the
population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite …

Abstract Sirtuin 2 (SIRT2) is an NAD+ dependent deacetylase that is the most abundant
sirtuin protein in the brain. Accumulating evidence revealed the role of SIRT2 in a wide …