Artificial intelligence-driven systems engineering for next-generation plant-derived biopharmaceuticals
S Parthiban, T Vijeesh, T Gayathri… - Frontiers in Plant …, 2023 - frontiersin.org
Recombinant biopharmaceuticals including antigens, antibodies, hormones, cytokines,
single-chain variable fragments, and peptides have been used as vaccines, diagnostics and …
single-chain variable fragments, and peptides have been used as vaccines, diagnostics and …
Strategies for improving the genome-editing efficiency of class 2 CRISPR/Cas system
L Wang, H Han - Heliyon, 2024 - cell.com
Since its advent, gene-editing technology has been widely used in microorganisms,
animals, plants, and other species. This technology shows remarkable application …
animals, plants, and other species. This technology shows remarkable application …
Predicting gene sequences with AI to study codon usage patterns
Selective pressure acts on the codon use, optimizing multiple, overlap** signals that are
only partially understood. We trained AI models to predict codons given their amino acid …
only partially understood. We trained AI models to predict codons given their amino acid …
Multiple strategies to improve extracellular secretion and activity of feruloyl esterase
S Zhang, J Wang, Y Liu, Z Xu - International Journal of Biological …, 2024 - Elsevier
Feruloyl esterase has a wide range of applications, but there are still problems with low
enzyme yield and activity, and complex purification steps. Our previous research found …
enzyme yield and activity, and complex purification steps. Our previous research found …
Codon-optimization in gene therapy: promises, prospects and challenges
AI Paremskaia, AA Kogan, A Murashkina… - … in Bioengineering and …, 2024 - frontiersin.org
Codon optimization has evolved to enhance protein expression efficiency by exploiting the
genetic code's redundancy, allowing for multiple codon options for a single amino acid …
genetic code's redundancy, allowing for multiple codon options for a single amino acid …
Development and immunogenicity evaluation of attenuated Salmonella typhimurium delivering porcine Deltacoronavirus S1 gene
J Yang, R Chen, M Sun, R Yuan, YF **ao, Y Sun… - International Journal of …, 2025 - Elsevier
Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic coronavirus that causes
severe diarrhea in piglets, the development of novel vaccines is of great value in the …
severe diarrhea in piglets, the development of novel vaccines is of great value in the …
AI Models for Biopharmaceutical Property Prediction
B Yingngam - Artificial Intelligence and Machine Learning in …, 2024 - Wiley Online Library
Accurate and reliable prediction of drug properties is crucial in the biopharmaceutical
industry because they directly impact drug efficacy and safety. However, the traditional …
industry because they directly impact drug efficacy and safety. However, the traditional …
Pre-trained protein language model for codon optimization
Abstract Motivation Codon optimization of Open Reading Frame (ORF) sequences is
essential for enhancing mRNA stability and expression in applications like mRNA vaccines …
essential for enhancing mRNA stability and expression in applications like mRNA vaccines …
Natural Language Processing for Language of Life (mRNA vaccine design)
S Pathak - 2024 - era.library.ualberta.ca
The COVID-19 pandemic accelerated the development of mRNA vaccines, yet identifying
the optimal mRNA sequence for human use, particularly for the SARS-CoV-2 spike protein …
the optimal mRNA sequence for human use, particularly for the SARS-CoV-2 spike protein …