Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

This year in review about osteoarthritis biology highlights a selection of articles published
between the 2019 and 2020 Osteoarthritis Research Society International (OARSI) World …

Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …

Osteoarthritis (OA) is one of the most prevalent chronic joint diseases worldwide, which
causes a series of problems, such as joint pain, muscle atrophy, and joint deformities …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

Osteoarthritis (OA) is a degenerative joint disease caused by chronic inflammation that
damages articular cartilage. At present, the treatment of OA includes drug therapy to relieve …

Minimally invasive repair strategies are a very promising approach for the treatment of
intervertebral disc degeneration (IDD). In recent years, small extracellular vesicles (sEVs) …

Chronic inflammation is implicated in numerous human pathologies. In particular, low-grade
inflammation is currently recognized as an important mechanism of osteoarthritis (OA), at …

The extracellular matrix (ECM) is an active and dynamic feature of tissues that not only
provides gross structure but also plays key roles in cellular responses. The ever-changing …