Alternative splicing: a pivotal step between eukaryotic transcription and translation
Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …
Alternative splicing: decoding an expansive regulatory layer
Alternative splicing (AS) is the process by which splice sites in precursor (pre)-mRNA are
differentially selected to produce multiple mRNA and protein isoforms. During the past few …
differentially selected to produce multiple mRNA and protein isoforms. During the past few …
The 3D-Evo space: evolution of gene expression and alternative splicing regulation
F Mantica, M Irimia - Annual Review of Genetics, 2022 - annualreviews.org
Animal species present relatively high levels of gene conservation, and yet they display a
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …
Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression
Transcription and pre-mRNA alternative splicing are highly regulated processes that play
major roles in modulating eukaryotic gene expression. It is increasingly apparent that other …
major roles in modulating eukaryotic gene expression. It is increasingly apparent that other …
Regulated functional alternative splicing in Drosophila
JP Venables, J Tazi, F Juge - Nucleic acids research, 2012 - academic.oup.com
Alternative splicing expands the coding capacity of metazoan genes, and it was largely
genetic studies in the fruit-fly Drosophila melanogaster that established the principle that …
genetic studies in the fruit-fly Drosophila melanogaster that established the principle that …
Functional coupling of transcription and splicing
The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing
is a key mechanism to increase the number and complexity of proteins encoded by the …
is a key mechanism to increase the number and complexity of proteins encoded by the …
The identification of protein and RNA interactors of the splicing factor Caper in the adult Drosophila nervous system
MB Titus, AW Chang, N Popitsch… - Frontiers in Molecular …, 2023 - frontiersin.org
Post-transcriptional gene regulation is a fundamental mechanism that helps regulate the
development and healthy aging of the nervous system. Mutations that disrupt the function of …
development and healthy aging of the nervous system. Mutations that disrupt the function of …
Encoding anatomy: developmental gene regulatory networks and morphogenesis
CA Ettensohn - genesis, 2013 - Wiley Online Library
A central challenge of developmental and evolutionary biology is to explain how anatomy is
encoded in the genome. Anatomy emerges progressively during embryonic development …
encoded in the genome. Anatomy emerges progressively during embryonic development …
Evolution of splicing regulatory networks in Drosophila
The proteome expanding effects of alternative pre-mRNA splicing have had a profound
impact on eukaryotic evolution. The events that create this diversity can be placed into four …
impact on eukaryotic evolution. The events that create this diversity can be placed into four …
Evolutionarily emerged G tracts between the polypyrimidine tract and 3′ AG are splicing silencers enriched in genes involved in cancer
M Sohail, W Cao, N Mahmood, M Myschyshyn… - BMC genomics, 2014 - Springer
Background The 3′ splice site (SS) at the end of pre-mRNA introns has a consensus
sequence (Y) n NYAG for constitutive splicing of mammalian genes. Deviation from this …
sequence (Y) n NYAG for constitutive splicing of mammalian genes. Deviation from this …