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Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
Antimalarial drug discovery: progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
Tuberculosis drug discovery: challenges and new horizons
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
Marine natural products
This review covers the literature published in 2019 for marine natural products (MNPs), with
719 citations (701 for the period January to December 2019) referring to compounds …
719 citations (701 for the period January to December 2019) referring to compounds …
New developments in anti-malarial target candidate and product profiles
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …
renewed focus on malaria elimination and eradication. Changes in the way new anti …
Approaches to advance drug discovery for neglected tropical diseases
Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …
Marine natural products
Covering: 2020 This review covers the literature published in 2020 for marine natural
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …
Natural products as a source for novel antibiotics
Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …
development of antibacterial agents. Interest in these systems has waned in recent years …
[HTML][HTML] Chemical probes and drug leads from advances in synthetic planning and methodology
CJ Gerry, SL Schreiber - Nature Reviews Drug Discovery, 2018 - nature.com
Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …
probes of disease-related targets and potential starting points for drug discovery. In this …