Mitochondria and reactive oxygen species in aging and age-related diseases
Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …
Mitochondrial Ca2+ and apoptosis
Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …
large body of experimental evidence has unambiguously revealed that, in addition to the …
Next-generation metal anticancer complexes: multitargeting via redox modulation
Platinum complexes are widely used anticancer drugs. New generations of metal
chemotherapeutics offer the prospect of combating platinum resistance and expanding the …
chemotherapeutics offer the prospect of combating platinum resistance and expanding the …
Mitochondrial oxidative stress and “mito-inflammation”: actors in the diseases
A decline in mitochondrial redox homeostasis has been associated with the development of
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2
Ferredoxin reductase (FDXR), a target of p53, modulates p53-dependent apoptosis and is
necessary for steroidogenesis and biogenesis of iron–sulfur clusters. To determine the …
necessary for steroidogenesis and biogenesis of iron–sulfur clusters. To determine the …
The FHIT gene product: tumor suppressor and genome “caretaker”
The FHIT gene at FRA3B is one of the earliest and most frequently altered genes in the
majority of human cancers. It was recently discovered that the FHIT gene is not the most …
majority of human cancers. It was recently discovered that the FHIT gene is not the most …
MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of solid cancers
US8148069B2 - MicroRNA-based methods and compositions for the diagnosis, prognosis and
treatment of solid cancers - Google Patents US8148069B2 - MicroRNA-based methods and …
treatment of solid cancers - Google Patents US8148069B2 - MicroRNA-based methods and …
[HTML][HTML] Hit proteins, mitochondria and cancer
The histidine triad (HIT) superfamily comprises proteins that share the histidine triad motif,
His-ϕ-His-ϕ-His-ϕ–ϕ, where ϕ is a hydrophobic amino acid. HIT proteins are ubiquitous in …
His-ϕ-His-ϕ-His-ϕ–ϕ, where ϕ is a hydrophobic amino acid. HIT proteins are ubiquitous in …
Identification of a Tumor-Suppressive Human-Specific MicroRNA within the FHIT Tumor-Suppressor Gene
Loss or attenuated expression of the tumor-suppressor gene FHIT is associated
paradoxically with poor progression of human tumors. Fhit promotes apoptosis and …
paradoxically with poor progression of human tumors. Fhit promotes apoptosis and …
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells
Two isoforms of sphingosine kinase, SK1 and SK2, catalyze the formation of the bioactive
lipid sphingosine 1-phosphate (S1P) in mammalian cells. We have previously shown that …
lipid sphingosine 1-phosphate (S1P) in mammalian cells. We have previously shown that …