The molecular hallmarks of epigenetic control
CD Allis, T Jenuwein - Nature Reviews Genetics, 2016 - nature.com
Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …
associated mechanisms that alter chromatin in response to physiological or pathological …
Regulation of type I interferon responses
LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …
development of innate and adaptive immune responses. Canonical type I IFN signalling …
Local regulation of gene expression by lncRNA promoters, transcription and splicing
Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …
mRNA regulation by RNA modifications
Chemical modifications on mRNA represent a critical layer of gene expression regulation.
Research in this area has continued to accelerate over the last decade, as more …
Research in this area has continued to accelerate over the last decade, as more …
Mechanisms and regulation of alternative pre-mRNA splicing
Y Lee, DC Rio - Annual review of biochemistry, 2015 - annualreviews.org
Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …
regulation of gene expression, providing significant expansion of the functional proteome of …
Short intronic repeat sequences facilitate circular RNA production
D Liang, JE Wilusz - Genes & development, 2014 - genesdev.cshlp.org
Recent deep sequencing studies have revealed thousands of circular noncoding RNAs
generated from protein-coding genes. These RNAs are produced when the precursor …
generated from protein-coding genes. These RNAs are produced when the precursor …
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing
NM Martinez, A Su, MC Burns, JK Nussbacher… - Molecular cell, 2022 - cell.com
Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …
Coupling mRNA processing with transcription in time and space
DL Bentley - Nature Reviews Genetics, 2014 - nature.com
Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
Transcription elongation can affect genome 3D structure
S Heinz, L Texari, MGB Hayes, M Urbanowski… - Cell, 2018 - cell.com
How transcription affects genome 3D organization is not well understood. We found that
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …
Alternative splicing: a pivotal step between eukaryotic transcription and translation
Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …