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Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …
whose composition changes as a function of an animal's physiological state. Ciliated …
Regulating endogenous neural stem cell activation to promote spinal cord injury repair
Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …
and treatment options to promote neural recovery are limited. An innovative approach to …
A harmonized atlas of mouse spinal cord cell types and their spatial organization
Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …
atlases of the mouse spinal cord have been published in recent years but have not been …
[HTML][HTML] Molecular architecture of the mouse nervous system
The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …
To facilitate scalable profiling of single cells, we developed split-pool ligation-based
transcriptome sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that …
transcriptome sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that …
Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica
Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a …
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a …
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Defects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the
mechanisms underlying detection of CSF flow in the central canal of the spinal cord are …
mechanisms underlying detection of CSF flow in the central canal of the spinal cord are …
The role of motile cilia in the development and physiology of the nervous system
C Ringers, EW Olstad… - … Transactions of the …, 2020 - royalsocietypublishing.org
Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …
Delineating the diversity of spinal interneurons in locomotor circuits
S Gosgnach, JB Bikoff, KJ Dougherty… - Journal of …, 2017 - jneurosci.org
Locomotion is common to all animals and is essential for survival. Neural circuits located in
the spinal cord have been shown to be necessary and sufficient for the generation and …
the spinal cord have been shown to be necessary and sufficient for the generation and …
[HTML][HTML] CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the
cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether …
cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether …