[HTML][HTML] Innate immune evasion by human respiratory RNA viruses

M Kikkert - Journal of innate immunity, 2020 - karger.com
The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool

D Lengerli, K Ibis, Y Nural… - Expert opinion on drug …, 2022 - Taylor & Francis
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …

[HTML][HTML] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

RA Flynn, JA Belk, Y Qi, Y Yasumoto, J Wei… - Cell, 2021 - cell.com
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using
comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) …

DEAD/H-box helicases: Anti-viral and pro-viral roles during infections

R Ullah, J Li, P Fang, S **ao, L Fang - Virus Research, 2022 - Elsevier
Abstract DEAD/H-box RNA helicases make the prominent family of helicases super family-2
which take part in almost all RNA-related processes, from initiation of transcription to RNA …

Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity

J Li, Y Zhou, W Zhao, J Liu, R Ullah, P Fang, L Fang… - Autophagy, 2023 - Taylor & Francis
Porcine reproductive and respiratory syndrome virus (PRRSV) is a typical
immunosuppressive virus devastating the global swine industry. DEAD-box helicases …

DEAD-box RNA helicases: The driving forces behind RNA metabolism at the crossroad of viral replication and antiviral innate immunity

MAM Ali - Virus Research, 2021 - Elsevier
DEAD-box RNA helicases, the largest family of superfamily 2 helicases, are a profoundly
conserved family of RNA-binding proteins, containing a distinctive Asp–Glu–Ala–Asp …

DDX21, a host restriction factor of FMDV IRES-dependent translation and replication

SW Abdullah, J Wu, Y Zhang, M Bai, J Guan, X Liu… - Viruses, 2021 - mdpi.com
In cells, the contributions of DEAD-box helicases (DDXs), without which cellular life is
impossible, are of utmost importance. The extremely diverse roles of the nucleolar helicase …

[HTML][HTML] DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

A Brai, V Riva, F Saladini, C Zamperini… - European Journal of …, 2020 - Elsevier
The huge resources that had gone into Human Immunodeficiency virus (HIV) research led to
the development of potent antivirals able to suppress viral load in the majority of treated …

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

J Fan, Z Li, L Pei, Y Hou - Genes & Diseases, 2024 - Elsevier
Hematopoiesis represents a meticulously regulated and dynamic biological process.
Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to …

ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions

S Tayal, V Bhatia, T Mehrotra, S Bhatnagar - Amino Acids, 2022 - Springer
Molecular mimicry of host proteins by pathogens constitutes a strategy to hijack the host
pathways. At present, there is no dedicated resource for mimicked domains and motifs in the …