The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …

The rapidly increasing quantity of genome-wide chromosome conformation capture data
presents great opportunities and challenges in the computational modeling and …

Chromosomes of all species studied so far display a variety of higher-order organisational
features, such as self-interacting domains or loops. These structures, which are often …

INTRODUCTION The overall organization of budding yeast chromosomes is driven and
regulated by four factors:(i) the tethering and clustering of centromeres at the spindle pole …

Genomic analyses of microbial populations in their natural environment remain limited by
the difficulty to assemble full genomes of individual species. Consequently, the chromosome …

Closing gaps in draft genome assemblies can be costly and time-consuming, and published
genomes are therefore often left 'unfinished.'Here we show that genome-wide chromosome …

Polyploidization plays a key role in plant evolution, but the forces driving the fate of
homoeologs in polyploid genomes, ie, paralogs resulting from a whole-genome duplication …

The development of new technologies and experimental techniques is enabling researchers
to see what was once unable to be seen. For example, the centromere was first seen as the …

Non‐model microorganisms have been increasingly explored as microbial cell factories for
production of chemicals, fuels, and materials owing to their unique physiology and metabolic …

In chromosome conformation capture experiments (Hi‐C), the accuracy with which contacts
are detected varies due to the uneven distribution of restriction sites along genomes. In …