High‐aspect‐ratio nanostructured surfaces as biological metamaterials
Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …
scales to cellular components. These surfaces are an extreme topography on the cellular …
Neuromorphic electronics based on copying and pasting the brain
Reverse engineering the brain by mimicking the structure and function of neuronal networks
on a silicon integrated circuit was the original goal of neuromorphic engineering, but …
on a silicon integrated circuit was the original goal of neuromorphic engineering, but …
A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons
Current electrophysiological or optical techniques cannot reliably perform simultaneous
intracellular recordings from more than a few tens of neurons. Here we report a …
intracellular recordings from more than a few tens of neurons. Here we report a …
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
Chronic imaging of neuronal networks in vitro has provided fundamental insights into
mechanisms underlying neuronal function. Current labeling and optical imaging methods …
mechanisms underlying neuronal function. Current labeling and optical imaging methods …
Development of in vitro 2D and 3D microelectrode arrays and their role in advancing biomedical research
The development of microelectrode arrays (MEAs) along with complementary advances in
electronics, mechanics and software to connect with these arrays has led to the in vitro …
electronics, mechanics and software to connect with these arrays has led to the in vitro …
High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp
Y Peng, FX Mittermaier, H Planert, UC Schneider… - Elife, 2019 - elifesciences.org
Comparing neuronal microcircuits across different brain regions, species and individuals
can reveal common and divergent principles of network computation. Simultaneous patch …
can reveal common and divergent principles of network computation. Simultaneous patch …
Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics
T Kobayashi, K Shimba, T Narumi, T Asahina… - Nature …, 2024 - nature.com
The synchronous activity of neuronal networks is considered crucial for brain function.
However, the interaction between single-neuron activity and network-wide activity remains …
However, the interaction between single-neuron activity and network-wide activity remains …
Nanotechnology: new opportunities for the development of patch‐clamps
J Gao, C Liao, S Liu, T **a, G Jiang - Journal of nanobiotechnology, 2021 - Springer
The patch-clamp technique is one of the best approaches to investigate neural excitability.
Impressive improvements towards the automation of the patch-clamp technique have been …
Impressive improvements towards the automation of the patch-clamp technique have been …
The potential of in vitro neuronal networks cultured on micro electrode arrays for biomedical research
M Cerina, MC Piastra, M Frega - Progress in Biomedical …, 2023 - iopscience.iop.org
In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …
Technologies to study action potential propagation with a focus on HD-MEAs
Axons convey information in neuronal circuits via reliable conduction of action potentials
(APs) from the axon initial segment (AIS) to the presynaptic terminals. Recent experimental …
(APs) from the axon initial segment (AIS) to the presynaptic terminals. Recent experimental …