Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus
(HIV) and remains a global health problem four decades after the report of its first case …

The Human immunodeficiency virus (HIV) is the causative agent of acquired
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …

Background Among some patients with human immunodeficiency virus type 1 (HIV-1)
infection who have undergone multiple antiretroviral therapies and have limited options for …

Background Fostemsavir, a prodrug of the first-in-class attachment inhibitor, temsavir, is
indicated for heavily treatment-experienced individuals with multidrug-resistant HIV-1. We …

Human immunodeficiency virus-1 (HIV-1) infection currently requires lifelong therapy with
drugs that are used in combination to control viremia. The indole-3-glyoxamide 6 was …

Summary While HIV-1-mediated CD4 downregulation protects infected cells from antibody-
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …

Abstract The HIV-1 envelope (Env) spike is a conformational machine that transitions
between prefusion (closed, CD4-and CCR5-bound) and postfusion states to facilitate HIV-1 …

Novel therapeutic options are urgently needed to improve global treatment of virus
infections. Herbal products with confirmed clinical safety features are attractive starting …

Abstract The Food and Drug Administration (FDA) has licensed many antiretroviral
medications to treat human immunodeficiency virus type 1 (HIV-1), however, treatment …

Human immunodeficiency virus (HIV) is a significant global health issue that affects a
substantial number of individuals across the globe, with a total of 39 million individuals living …