Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …

Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress
granules are important in the stress response and may contribute to some degenerative …

Stress granules (SG) are membrane‐less compartments involved in regulating mRNAs
during stress. Aberrant forms of SGs have been implicated in age‐related diseases, such as …

Aggregation of the RNA‐binding protein TAR DNA‐binding protein 43 (TDP‐43) is the key
neuropathological feature of neurodegenerative diseases, including amyotrophic lateral …

Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …

Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein
encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and …

© 2013 Li et al. This article is distributed under the terms of an Attribution–Noncommercial–
Share Alike–No Mirror Sites license for the first six months after the publication date (see …

Several recent breakthroughs have provided notable insights into the pathogenesis of
amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this …

Stress granules and P bodies are conserved cytoplasmic aggregates of nontranslating
messenger ribonucleoprotein complexes (mRNPs) implicated in the regulation of mRNA …