Immune checkpoint (ICP) molecules expressed on tumor cells can suppress immune
responses against tumors. ICP therapy promotes anti-tumor immune responses by targeting …

Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene
generating a great hope due to their outstanding specificity and potency. However, given …

Despite the fact that numerous immunotherapy-based drugs have been approved by the
FDA for the treatment of primary and metastatic tumors, only a small proportion of the …

T cells are often referred to as the 'guided missiles' of our immune system because of their
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …

T cell therapy shows promise as an immunotherapy in both immunostimulatory and
immunosuppressive applications. However, the forms of T cell-based therapy that are …

Cold tumors lack antitumor immunity and are resistant to therapy, representing a major
challenge in cancer medicine. Because of the immunosuppressive spirit of the tumor …