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Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders
Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental
disorders and to guide intervention decisions. These criteria also provide the organising …
disorders and to guide intervention decisions. These criteria also provide the organising …
Rare coding variation provides insight into the genetic architecture and phenotypic context of autism
Some individuals with autism spectrum disorder (ASD) carry functional mutations rarely
observed in the general population. We explored the genes disrupted by these variants from …
observed in the general population. We explored the genes disrupted by these variants from …
[HTML][HTML] Single-cell brain organoid screening identifies developmental defects in autism
The development of the human brain involves unique processes (not observed in many
other species) that can contribute to neurodevelopmental disorders,,–. Cerebral organoids …
other species) that can contribute to neurodevelopmental disorders,,–. Cerebral organoids …
[HTML][HTML] Genetic causes and modifiers of autism spectrum disorder
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
[HTML][HTML] A cross-disorder dosage sensitivity map of the human genome
Rare copy-number variants (rCNVs) include deletions and duplications that occur
infrequently in the global human population and can confer substantial risk for disease. In …
infrequently in the global human population and can confer substantial risk for disease. In …
[HTML][HTML] Clinical assessment, genetics, and treatment approaches in autism spectrum disorder (ASD)
Autism spectrum disorder (ASD) consists of a genetically heterogenous group of
neurobehavioral disorders characterized by impairment in three behavioral domains …
neurobehavioral disorders characterized by impairment in three behavioral domains …
Inherited and de novo genetic risk for autism impacts shared networks
We performed a comprehensive assessment of rare inherited variation in autism spectrum
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
Use of race, ethnicity, and ancestry data in health research
Race, ethnicity, and ancestry are common classification variables used in health research.
However, there has been no formal agreement on the definitions of these terms, resulting in …
However, there has been no formal agreement on the definitions of these terms, resulting in …