Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …

Thyroid peroxidase (TPO) is a heme binding protein localized on the apical membrane of
the thyrocyte. TPO enzymatic activity is essential for thyroid hormonogenesis. Inactivating …

Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for
growth, development and the control of metabolism in vertebrates,. Hormone synthesis from …

In thyrocytes, cell polarity is of crucial importance for proper thyroid function. Many intrinsic
mechanisms of self-regulation control how the key players involved in thyroid hormone (TH) …

Thyroglobulin (TG) defects due to TG gene mutations have an estimated incidence of
approximately 1 in 100,000 newborns. This dyshormonogenesis displays a wide phenotype …

Thyroglobulin (Tg) is a large molecule containing 2750 amino acids with a molecular weight
of 330 kD and twenty putative N-linked glycosylation sites. Tg gene expression is regulated …

Autoimmune thyroid diseases are common polygenic multifactorial disorders with the
environment contributing importantly to the emergence of the disease phenotype. Some of …

Background Congenital hypothyroidism (CH) is the most common neonatal endocrine
disorder in infancy. Dual oxidase 2 gene (DUOX2) mutations have been reported to be one …

Advances in the understanding of thyroglobulin genetic defects and its severity should allow
researchers to perform adequate molecular diagnosis, genetic counseling, and intrauterine …

Thyroid hormonogenesis requires secretion of thyroglobulin, a protein comprising Cys-rich
regions I, II, and III (referred to collectively as region I-II-III) followed by a cholinesterase-like …