Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Decades of neuroimaging studies have shown modest differences in brain structure and
connectivity in depression, hindering mechanistic insights or the identification of risk factors …

Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

Chronic stress and depressive-like behaviors in basic neuroscience research have been
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …

Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …

Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …

Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory
and higher-order cognitive processing. Connectome studies have suggested a principal …