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Targeting and engineering long non-coding RNAs for cancer therapy
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …
Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …
the origin, course of action and treatment of any disease state is essential. A microscopic …
Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk
Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …
Functional classification and experimental dissection of long noncoding RNAs
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …
species are pervasively transcribed, resulting in the production of numerous long noncoding …
The functions and unique features of long intergenic non-coding RNA
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
Long non-coding RNA mediated drug resistance in breast cancer
Breast cancer is one of the most prevalent cancers in women and a leading cause of
mortality. As per the GLOBCAN report of 2021, breast cancer has surpassed lung cancer …
mortality. As per the GLOBCAN report of 2021, breast cancer has surpassed lung cancer …
Non-coding RNAs and potential therapeutic targeting in cancer
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …
Long noncoding RNAs in cancer pathways
AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …
mutations within the noncoding genome, with profound effects on the expression of long …
A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth
A substantial fraction of eukaryotic transcripts are considered long non-coding RNAs
(lncRNAs), which regulate various hallmarks of cancer. Here, we discovered that the lncRNA …
(lncRNAs), which regulate various hallmarks of cancer. Here, we discovered that the lncRNA …
Long non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy
Y Qian, L Shi, Z Luo - Frontiers in medicine, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that are
arising as important players in various biological pathways. They have received extensive …
arising as important players in various biological pathways. They have received extensive …