Targeting and engineering long non-coding RNAs for cancer therapy

M Coan, S Haefliger, S Ounzain, R Johnson - Nature Reviews Genetics, 2024 - nature.com
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk

M Ahmad, LB Weiswald, L Poulain, C Denoyelle… - Journal of Experimental …, 2023 - Springer
Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …

Functional classification and experimental dissection of long noncoding RNAs

F Kopp, JT Mendell - Cell, 2018 - cell.com
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …

The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

Long non-coding RNA mediated drug resistance in breast cancer

D Singh, YG Assaraf, RN Gacche - Drug Resistance Updates, 2022 - Elsevier
Breast cancer is one of the most prevalent cancers in women and a leading cause of
mortality. As per the GLOBCAN report of 2021, breast cancer has surpassed lung cancer …

Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

Long noncoding RNAs in cancer pathways

AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth

JZ Huang, M Chen, DE Chen, XC Gao, S Zhu, H Huang… - Molecular cell, 2017 - cell.com
A substantial fraction of eukaryotic transcripts are considered long non-coding RNAs
(lncRNAs), which regulate various hallmarks of cancer. Here, we discovered that the lncRNA …

Long non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy

Y Qian, L Shi, Z Luo - Frontiers in medicine, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that are
arising as important players in various biological pathways. They have received extensive …