Determinants of glycosaminoglycan (GAG) structure

K Prydz - Biomolecules, 2015 - mdpi.com
Proteoglycans (PGs) are glycosylated proteins of biological importance at cell surfaces, in
the extracellular matrix, and in the circulation. PGs are produced and modified by …

Calcium sensors in neuronal function and dysfunction

RD Burgoyne, N Helassa… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

[HTML][HTML] Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus

A Karpova, M Mikhaylova, S Bera, J Bär, PP Reddy… - Cell, 2013 - cell.com
The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity
and cell survival signals, whereas NMDARs residing in the neuronal membrane outside …

The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer)

MG Waugh - Biochemical journal, 2019 - portlandpress.com
Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …

APOL1 C-terminal variants may trigger kidney disease through interference with APOL3 control of actomyosin

S Uzureau, L Lecordier, P Uzureau, D Hennig… - Cell reports, 2020 - cell.com
The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance
to the slee** sickness parasite Trypanosoma rhodesiense, but they also increase the risk …

A dendritic Golgi satellite between ERGIC and retromer

M Mikhaylova, S Bera, O Kobler, R Frischknecht… - Cell reports, 2016 - cell.com
The local synthesis of transmembrane proteins underlies functional specialization of
dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have …

Cinderella story: PI4P goes from precursor to key signaling molecule

J Tan, JA Brill - Critical reviews in biochemistry and molecular …, 2014 - Taylor & Francis
Phosphatidylinositol lipids are signaling molecules involved in nearly all aspects of cellular
regulation. Production of phosphatidylinositol 4-phosphate (PI4P) has long been recognized …

Apolipoproteins L1 and L3 control mitochondrial membrane dynamics

L Lecordier, P Heo, JH Graversen, D Hennig… - Cell reports, 2023 - cell.com
Summary Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the
membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular …

Research progress on phosphatidylinositol 4-kinase inhibitors

G Li, Y Wu, Y Zhang, H Wang, M Li, D He… - Biochemical …, 2024 - Elsevier
Abstract Phosphatidylinositol 4-kinases (PI4Ks) could phosphorylate phosphatidylinositol
(PI) to produce phosphatidylinositol 4-phosphate (PI4P) and maintain its metabolic balance …

The diversity of calcium sensor proteins in the regulation of neuronal function

HV McCue, LP Haynes… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
Calcium signaling in neurons as in other cell types mediates changes in gene expression,
cell growth, development, survival, and cell death. However, neuronal Ca2+ signaling …