The natural switch from fever to hypothermia observed in the most severe cases of systemic
inflammation is a phenomenon that continues to puzzle clinicians and scientists. The …

Bacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways
involving cytokine production, blood coagulation, complement system activation, and acute …

The efferent branches of the splanchnic sympathetic nerves that enhance interleukin‐10 (IL‐
10) and suppress tumour necrosis factor‐α (TNF) levels in the reflex response to systemic …

Placental P-glycoprotein (P-gp) acts to protect the develo** fetus from exogenous
compounds. This protection declines with advancing gestation leaving the fetus and fetal …

Disruption of the alveolar–endothelial barrier caused by inflammation leads to the
progression of septic acute lung injury (ALI). In the present study, we investigated the …

Increasing evidence suggests that apoptosis of tubular cells and renal inflammation mainly
determine the outcome of sepsis-associated acute kidney injury (AKI). The study aim was to …

This study is aimed to investigate whether simvastatin induces cardiomyocytes survival
signaling in endotoxin (lipopolysaccharide, LSP)-induced myocardial injury, and if so, further …

Background/Aim. Recurrent aphthous stomatitis (RAS) is defined as multifactor immunologic
inflammatory lesions in the oral cavity, characterized by painful, recurrent single/multiple …

Endotoxemia is associated by dysregulated apoptosis of immune and non-immune cells. We
investigated whether simvastatin has anti-apoptotic effects, and induces hepatocytes and …

Cardiac surgical patients often have associated comorbidities that can impede normal
wound healing; however, statin therapy has the potential to improve this process through …