Peroxisomes contribute to several crucial metabolic processes such as β-oxidation of fatty
acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species …

Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

The peroxisomal protein import machinery differs fundamentally from known translocons
(endoplasmic reticulum, mitochondria, chloroplasts, bacteria) as it allows membrane …

Peroxisomes are organelles that carry out β-oxidation of fatty acids and amino acids. Both
rare and prevalent diseases are caused by their dysfunction. Among disease-causing …

Accumulating evidence indicates that peroxisome functioning, catalase localization, and
cellular oxidative balance are intimately interconnected. Nevertheless, it remains largely …

According to current models of peroxisomal biogenesis, newly synthesized peroxisomal
matrix proteins are transported into the organelle by Pex5p. Pex5p recognizes these …

Despite the large amounts of H 2 O 2 generated in mammalian peroxisomes, cysteine
residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry …

Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized
peroxisomal matrix proteins in the cytosol and promotes their translocation across the …

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported
into the organelle by a complex machinery. The data gathered in recent years suggest that …

The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …