Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Primary cilia are rod-like sensory organelles that protrude from the surface of most
mammalian cells, including the cells of the islet, and mounting evidence supports important …

Primary cilia are sensory organelles present in many cell types, partaking in various
signaling processes. Primary cilia of pancreatic beta cells play pivotal roles in paracrine …

Diabetes results from an inadequate number of insulin-producing human beta cells. There is
currently no clinically available effective means to restore beta cell mass in millions of …

Polygenic risk score (PRS) is a widely used approach for predicting individuals' genetic risk
of complex diseases, playing a pivotal role in advancing precision medicine. Traditional …

Pancreatic islet cells harbor primary cilia, small sensory organelles that detect
environmental changes to regulate hormone secretion and intercellular communication …

Genetic and epigenetic alterations are cancer hallmark characteristics. However, the role of
inherited cancer predisposition alleles in co‐opting lineage factor epigenetic reprogramming …

Translational efforts in osteoarthritis are hampered by a gap in our understanding of disease
processes at the molecular level. Here, we present evidence of pronounced transcriptional …

The Cullin-3 E3 ligase adaptor protein SPOP targets proteins for ubiquitination and
proteasomal degradation. We previously established the β-cell transcription factor (TF) and …

Abstract Glucose-6-phosphatase catalytic subunit (G6PC) 1 and G6PC2 are crucial for
glucose metabolism, regulating processes like glycolysis, gluconeogenesis, and …