The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Stroke is the primary cause of disability due to the brain's limited ability to regenerate
damaged tissue. After stroke, an increased inflammatory and immune response coupled …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Nerves are emerging regulators of cancer progression. Cancer cells induce the outgrowth of
nerves in the tumor microenvironment through the release of neurotrophic factors, and in …

Retinal microvasculature is crucial for the visual function of the neural retina. Pericytes and
endothelial cells (ECs) are the two main cellular constituents in the retinal microvessels …

Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …

Most of the currently available drugs for osteoporosis inhibit osteoclastic bone resorption;
only a few drugs promote osteoblastic bone formation. It is thus becoming increasingly …