Host cell glutamine metabolism as a potential antiviral target

SM Hirabara, R Gorjao, AC Levada-Pires… - Clinical …, 2021 - portlandpress.com
A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome
and capsid together are known as the nucleocapsid, which has an envelope containing a …

Production of a foot-and-mouth disease vaccine antigen using suspension-adapted BHK-21 cells in a bioreactor

S Park, JY Kim, KH Ryu, AY Kim, J Kim, YJ Ko, EG Lee - Vaccines, 2021 - mdpi.com
The baby hamster kidney-21 (BHK-21) cell line is a continuous cell line used to propagate
foot-and-mouth disease (FMD) virus for vaccine manufacturing. BHK-21 cells are anchorage …

The Stability and Efficency of CPB Cells Were Acclimated for Virus Proliferation

Y Niu, S Ma, H Liang, X Fu, B Ma, Q Lin, X Luo, N Li - Vaccines, 2024 - mdpi.com
Background: Vaccinations are still the most effective means of preventing and controlling
fish viral diseases, and cells are an important substrate for the production of a viral vaccine …

Investigation of the optimal medium and application strategy for foot‐and‐mouth disease vaccine antigen production

AY Kim, H Kim, SY Park, SH Park… - Journal of Applied …, 2021 - academic.oup.com
Aims For the effective production of 146S particles, which determines foot‐and‐mouth
disease (FMD) vaccine efficacy, we aimed to identify the optimal medium that is easy‐to …

Lactate is useful for the efficient replication of porcine epidemic diarrhea virus in cell culture

N Wuri, H Gou, B Zhang, M Wang, S Wang… - Frontiers in Veterinary …, 2023 - frontiersin.org
Porcine epidemic diarrhea virus (PEDV) is a deadly pathogen infecting pig herds, and has
caused significant economic losses around the world. Vaccination remains the most …

High-Titer hepatitis C virus production in a scalable single-use high cell density bioreactor

A Offersgaard, CR Duarte Hernandez, AF Pihl… - Vaccines, 2022 - mdpi.com
Hepatitis C virus (HCV) infections pose a major public health burden due to high chronicity
rates and associated morbidity and mortality. A vaccine protecting against chronic infection …

Effect of cell density on the biological titer and yield of 146S fraction of foot-and-mouth disease virus O in cell suspension

A Rizvi, N Hussain, AA Anjum, N Ahmed… - Journal of Virological …, 2022 - Elsevier
Foot-and-mouth disease (FMD) is a highly infectious disease of cattle and other cloven-
hoofed animals, causing huge economic losses annually worldwide. This disease is …

Upstream Processing of Viral Therapeutics: From Host Cell Expansion to Virus Production

O Hamusics, D Loewe - Bioprocess and Analytics Development for Virus …, 2023 - Springer
Viral vectors have emerged as a promising approach to treat genetic diseases and cancers,
marking the start of a new era in the pharmaceutical industry. But this new category of potent …

[PDF][PDF] High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor. Vaccines 2022, 10, 249

A Offersgaard, CR Duarte Hernandez, A Finne Pihl… - 2022 - academia.edu
Hepatitis C virus (HCV) infections pose a major public health burden due to high chronicity
rates and associated morbidity and mortality. A vaccine protecting against chronic infection …

[CITATION][C] Development and Optimization of Serum-Free Medium for High-density Culture of Suspended BHK-21 Cells and High-yield of FMD Virus

M CHEN, X LIU, L ZHAO - Biotechnology Bulletin, 2020