Spirocyclic scaffolds in medicinal chemistry
Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The
increasing interest in less planar bioactive compounds has given rise to the development of …
increasing interest in less planar bioactive compounds has given rise to the development of …
Pyrrolidine in drug discovery: a versatile scaffold for novel biologically active compounds
The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by
medicinal chemists to obtain compounds for the treatment of human diseases. The great …
medicinal chemists to obtain compounds for the treatment of human diseases. The great …
Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: bioactivity, cytotoxicity, and molecular modeling studies
Despite significant developments in therapeutic strategies, Diabetes Mellitus remains an
increasing concern, leading to various complications, eg, cataracts, neuropathy, retinopathy …
increasing concern, leading to various complications, eg, cataracts, neuropathy, retinopathy …
Structural characterization of the millennial antibacterial (fluoro) quinolones—sha** the fifth generation
The evolution of the class of antibacterial quinolones includes the introduction in therapy of
highly successful compounds. Although many representatives were withdrawn due to …
highly successful compounds. Although many representatives were withdrawn due to …
ipso-Cyclization of unactivated biaryl ynones leading to thio-functionalized spirocyclic enones
CR Reddy, U Ajaykumar, AD Patil… - Organic & Biomolecular …, 2023 - pubs.rsc.org
Ceric ammonium nitrate (CAN)-promoted oxidative ipso-cyclization of unactivated biaryl
ynones with S-centered radicals (SCN/SCF3) to access spiro [5, 5] trienones has been …
ynones with S-centered radicals (SCN/SCF3) to access spiro [5, 5] trienones has been …
Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity
Ł Pecio, S Pecio, T Mroczek, W Oleszek - Molecules, 2023 - mdpi.com
Based on the literature data from 1973 to 2022, this work summarizes reports on spiro-
flavonoids with a spiro-carbon at the center of their structure and how this affects their …
flavonoids with a spiro-carbon at the center of their structure and how this affects their …
Recent advances in catalytic enantioselective synthesis of pyrazolones with a tetrasubstituted stereogenic center at the 4-position
Pyrazolone [2, 4-dihydro-3H-pyrazol-4-one] represents one of the most important five-
membered nitrogen heterocycles which is present in numerous pharmaceutical drugs and …
membered nitrogen heterocycles which is present in numerous pharmaceutical drugs and …
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies
This paper describes the rational development of a series of novel spiroindoline derivatives
endowed with selective inhibitory activity on the HDAC6 isoform. A convenient …
endowed with selective inhibitory activity on the HDAC6 isoform. A convenient …
Enantioselective Synthesis of Functionalized Diazaspirocycles from 4‐Benzylideneisoxazol‐5(4H)‐one Derivatives and Isocyanoacetate Esters
P Martínez‐Pardo, A Laviós… - Advanced Synthesis …, 2020 - Wiley Online Library
Enantioenriched spirocyclic compounds bearing three contiguous stereocenters and high
functionalization were obtained through a formal [3+ 2] cycloaddition reaction catalyzed by a …
functionalization were obtained through a formal [3+ 2] cycloaddition reaction catalyzed by a …
Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents
H Zhu, X Song, Y Pan, M Li, L Chen, P **ao… - European Journal of …, 2023 - Elsevier
Glioblastoma (GBM) is an aggressive brain tumor with extremely limited clinical treatment
options. Because of the blood–brain barrier (BBB), it is difficult for anti-GBM drug candidates …
options. Because of the blood–brain barrier (BBB), it is difficult for anti-GBM drug candidates …