Nuclear receptors (NRs) regulate tissue development and function by controlling
transcription from distinct sets of genes in response to fluctuating levels of hormones or cues …

Nuclear hormone receptors (NRs) are evolutionarily conserved ligand-dependent
transcription factors. They are essential for human life, mediating the actions of lipophilic …

Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast
cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by …

Normal progression through the cell cycle requires the sequential action of cyclin-dependent
kinases CDK1, CDK2, CDK4, and CDK6. Direct or indirect deregulation of CDK activity is a …

A key strategy to achieve regulated gene expression in higher eukaryotes is to prevent
illegitimate signal-independent activation by imposing robust control on the dismissal of …

The DEAD-box RNA helicases p68 (DDX5) and p72 (DDX17) have been shown to act as
transcriptional co-activators for a diverse range of transcription factors, including oestrogen …

Cyclin-dependent protein kinases (CDKs) are central to the appropriate regulation of cell
proliferation, apoptosis, and gene expression. Abnormalities in CDK activity and regulation …

Normal transcription displays a high degree of flexibility over the choice, timing and
magnitude of mRNA expression levels that tend to oscillate and cycle. These processes …

Polycyclic aromatic hydrocarbons such as benzo [a] pyrene (BaP) that activate the aryl
hydrocarbon receptor (Ahr) pathway, and endocrine disruptors acting through the estrogen …

Transcriptional corepressor proteins have emerged as an important facet of cancer etiology.
These corepressor proteins are often altered by loss-or gain-of-function mutations, leading …