The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

Purpose Cerebral ischemia induces a profound neuro-inflammatory response, but the
underlying molecular mechanisms are poorly understood. Inflammasomes (NLRP1, NLRP3 …

The use of dietary or medicinal plant based natural compounds to disease treatment has
become a unique trend in clinical research. Flavonoids, a group of polyphenolic compounds …

Background Microglia are important for secreting chemical mediators of inflammatory
responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells …

Severe neuroinflammation is associated with blood brain barrier (BBB) disruption in CNS
diseases. Although microglial activation and the subsequent changes in cytokine/chemokine …

Neurodegenerative disorders, particularly in the elderly population, represent one of the
most pressing social and health-care problems in the world. Besides the well-established …

Background Dexmedetomidine (Dex) was reported to exhibit anti-inflammatory effect in the
nervous system. However, the mechanism by which Dex exhibits anti-inflammation effects …

Usually, polyphenols help address numerous health issues caused by oxidative stress. Tea
is a popular beverage (rich in polyphenols) with abundant health promoting and disease …

Oxidative stress damage can lead to premature skin aging or age‐related skin disorders.
Therefore, strategies to improve oxidative stress‐induced aging are needed to protect the …

The NLRP3 inflammasome holds a crucial role in innate immune responses. Pathogen-and
danger-associated molecular patterns may initiate inflammasome activation and following …