Background: Articular cartilage lesions occur frequently but unfortunately damaged cartilage
has a very limited intrinsic repair capacity. Therefore, there is a high need to develop …

Large bone defects represent a significant challenge for clinicians and surgeons. Tissue
engineering for bone regeneration represents an innovative solution for this dilemma and …

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, belong to the most
prescribed analgesic medication after traumatic injuries. However, there is accumulating …

Critical-size bone defects are those that will not heal without intervention and can arise
secondary to trauma, infection, and surgical resection of tumors. Treatment options are …

Orthopedic tumor resection, trauma, or degenerative disease surgeries can result in large
bone defects and often require bone grafting. However, standard autologous bone grafting …

Objectives: To determine the efficacy of a preoperative fascia iliaca compartment block in
decreasing postoperative pain and improving functional recovery after hip fracture surgery …

Angiogenesis is essential for successful bone defect repair. In normal tissue repair, the
physiological inflammatory response is the main regulator of angiogenesis through the …

Aim Platelet‐rich plasma (PRP) is an autologous blood‐derived material that has been used
to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes …

Non-steroidal, anti-inflammatory drugs and statins are two widely prescribed drug classes
that affect bone formation. The aim of this study was to elucidate the effect of diclofenac and …

Background Patients with pre-existing neurodegenerative disease commonly experience
fractures that require orthopedic surgery. Perioperative neurocognitive disorders (PND) …