The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first map** of N6-methyladenosine (m6A) and …

RNA modifications play critical roles in the regulation of various biological processes and
are associated with many human diseases. Direct identification of RNA modifications by …

methylcytosine (m 5 C) is a post-transcriptional RNA modification identified in both stable
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …

5-methylcytosine (m5C) is an abundant RNA modification that's presence is reported in a
wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs …

Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally.
Recent studies suggested the widespread presence of N 1-methyladenosine (m1A), which …

RNA modifications are emerging players in the field of post-transcriptional regulation of
gene expression, and are attracting a comparable degree of research interest to DNA and …

Abstract m6A is a prevalent internal modification in mRNAs and has been linked to the
diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we …