Chemically modified platforms for better RNA therapeutics

Y Shi, X Zhen, Y Zhang, Y Li, S Koo, Q Saiding… - Chemical …, 2024 - ACS Publications
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment

S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

TAM family kinases as therapeutic targets at the interface of cancer and immunity

D DeRyckere, JM Huelse, HS Earp… - Nature Reviews Clinical …, 2023 - nature.com
Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for biomedical sensing

Y Sun, P Sun, Z Li, L Qu, W Guo - Chemical Society Reviews, 2022 - pubs.rsc.org
Fluorescent probes that emit in the far-red (600–700 nm), first near-infrared (NIR-I, 700–900
nm), and second NIR (NIR-II, 900–1700 nm) regions possess unique advantages, including …

Modified nucleic acid aptamers: development, characterization, and biological applications

D Ji, H Feng, SW Liew, CK Kwok - Trends in Biotechnology, 2023 - cell.com
Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural
interactions. To improve the properties and performance of aptamers, modified nucleotides …

Programmable melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies

X Ren, R Xue, Y Luo, S Wang, X Ge, X Yao, L Li… - Nature …, 2024 - nature.com
Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to
enhance antitumor effects and offers emerging opportunities for treating invasive tumor …

[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging

M Liu, L Wang, Y Lo, SCC Shiu, AB Kinghorn… - Cells, 2022 - mdpi.com
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …

Chemiluminescence sensing for Hg2+ in environment water using carbon materials from PVC dechlorination as signal initiator

Y Qi, Z **ng, F **u, Y Wang, X Gao - Analytical and Bioanalytical …, 2024 - Springer
Chemiluminescence (CL) sensing with good performance remains a challenge. The
utilization of secondary residues from polyvinyl chloride (PVC) treatment is the key to …

Molecular Engineering of Aptamer Self-Assemblies Increases in Vivo Stability and Targeted Recognition

F **a, A He, H Zhao, Y Sun, Q Duan, SJ Abbas, J Liu… - ACS …, 2021 - ACS Publications
Functionally modified aptamer conjugates are promising tools for targeted imaging or
treatment of various diseases. However, broad applications of aptamer molecules are …

Recent advancements of aptamers in cancer therapy

S Venkatesan, K Chanda, MM Balamurali - ACS omega, 2023 - ACS Publications
Aptamers are chemical antibodies possessing the capability of overcoming the limitations
posed by conventional antibodies, particularly for diagnostic, therapeutic, and theranostic …