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Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
libraries, presenting high affinity and specificity toward targets with similar to antibodies …
TAM family kinases as therapeutic targets at the interface of cancer and immunity
D DeRyckere, JM Huelse, HS Earp… - Nature Reviews Clinical …, 2023 - nature.com
Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …
resistance to current anticancer therapies in cancer cells and the tumour immune …
Natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for biomedical sensing
Fluorescent probes that emit in the far-red (600–700 nm), first near-infrared (NIR-I, 700–900
nm), and second NIR (NIR-II, 900–1700 nm) regions possess unique advantages, including …
nm), and second NIR (NIR-II, 900–1700 nm) regions possess unique advantages, including …
Modified nucleic acid aptamers: development, characterization, and biological applications
Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural
interactions. To improve the properties and performance of aptamers, modified nucleotides …
interactions. To improve the properties and performance of aptamers, modified nucleotides …
Programmable melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies
X Ren, R Xue, Y Luo, S Wang, X Ge, X Yao, L Li… - Nature …, 2024 - nature.com
Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to
enhance antitumor effects and offers emerging opportunities for treating invasive tumor …
enhance antitumor effects and offers emerging opportunities for treating invasive tumor …
[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …
for a plethora of therapeutic and diagnostic applications. Such applications include drug …
Chemiluminescence sensing for Hg2+ in environment water using carbon materials from PVC dechlorination as signal initiator
Y Qi, Z **ng, F **u, Y Wang, X Gao - Analytical and Bioanalytical …, 2024 - Springer
Chemiluminescence (CL) sensing with good performance remains a challenge. The
utilization of secondary residues from polyvinyl chloride (PVC) treatment is the key to …
utilization of secondary residues from polyvinyl chloride (PVC) treatment is the key to …
Molecular Engineering of Aptamer Self-Assemblies Increases in Vivo Stability and Targeted Recognition
Functionally modified aptamer conjugates are promising tools for targeted imaging or
treatment of various diseases. However, broad applications of aptamer molecules are …
treatment of various diseases. However, broad applications of aptamer molecules are …
Recent advancements of aptamers in cancer therapy
S Venkatesan, K Chanda, MM Balamurali - ACS omega, 2023 - ACS Publications
Aptamers are chemical antibodies possessing the capability of overcoming the limitations
posed by conventional antibodies, particularly for diagnostic, therapeutic, and theranostic …
posed by conventional antibodies, particularly for diagnostic, therapeutic, and theranostic …