The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

The development of vascular networks in microfluidic chips is crucial for the long-term
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …

Organ-on-chip (OOC) systems are revolutionizing tissue engineering by providing dynamic
models of tissue structure, organ-level function, and disease phenotypes using human cells …

Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Organ chips can recapitulate organ-level (patho) physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here …

Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …