Ferulic acid is being screened in preclinical settings to combat various neurological
disorders. It is a naturally occurring dietary flavonoid commonly found in grains, fruits, and …

Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for the poor prognosis
of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic …

Cadmium (Cd), a nonbiodegradable heavy metal and one of the most neurotoxic
environmental and industrial pollutants, promotes disturbances in major organs and tissues …

Acute or chronic liver injury is associated with hyperammonemia which induced
neuroinflammation and oxidative stress in the brain. Neuroinflammation, oxidative stress …

Oxidative stress has been considered the main mediator in neurodegenerative disease and
in normal aging processes. Several studies have reported that the accumulation of reactive …

The potential of duloxetine-loaded solid lipid nanoparticles (DLX-SLNs) for enhanced
antidepressant activity was investigated in the current study. Nano-template engineering …

The aim of this study was to develop paroxetine (PXT) loaded nanotransferosomal gel (PXT-
NTFG) for intranasal brain delivery. The process involved fabricating PXT-NTFs (paroxetine …

Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative
diseases. The current study aimed to synthesize a series of novel succinamide derivatives …

The current study explores the potential of melatonin (MLT)-loaded solid lipid nanoparticles
(MLT-SLNs) for better neuroprotective effects in ischemic stroke. MLT-SLNs were prepared …

Stroke ranks as the world's second most prevalent cause of mortality, and it represents a
major public health concern with profound economic and social implications. In the present …