Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Cardioprotection by salvage of the infarct-affected myocardium is an unmet yet highly
desired therapeutic goal. To develop new dedicated therapies, experimental myocardial …

Light‐sheet fluorescence microscopy (LSFM) introduces fast scanning of biological
phenomena with deep photon penetration and minimal phototoxicity. This advancement …

Blood flow and mechanical forces in the ventricle are implicated in cardiac development and
trabeculation. However, the mechanisms of mechanotransduction remain elusive. This is …

Tissue imaging in 3D using visible light is limited and various clearing techniques were
developed to increase imaging depth, but none provides universal solution for all tissues at …

The complex and highly organized structural arrangement of some five billion
cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the …

Hemodynamic shear force has been implicated as modulating Notch signaling–mediated
cardiac trabeculation. Whether the spatiotemporal variations in wall shear stress (WSS) …

We report a novel fusion of droplet microfluidics and light-sheet microscopy, to achieve high-
throughput sample compartmentalization, manipulation and three-dimensional imaging on a …

Many extensible tissues such as skin, lungs, and blood vessels require elasticity to function
properly. The recoil of elastic energy stored during a stretching phase is provided by elastic …