The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis and septic shock

NJ Meyer, HC Prescott - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Sepsis and Septic Shock Sepsis is a syndrome of life-threatening acute organ
dysfunction due to bacterial, fungal, parasitic, or viral infection. Factors that affect the risk of …

Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine

S Cajander, M Kox, BP Scicluna… - The Lancet …, 2024 - thelancet.com
Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

[HTML][HTML] Vitamin C and immune function

AC Carr, S Maggini - Nutrients, 2017 - mdpi.com
Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its
ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic …

The role of micronutrients in support of the immune response against viral infections

F Pecora, F Persico, A Argentiero, C Neglia, S Esposito - Nutrients, 2020 - mdpi.com
Viral infections are a leading cause of morbidity and mortality worldwide, and the importance
of public health practices including handwashing and vaccinations in reducing their spread …

Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges

G Voiriot, M Oualha, A Pierre… - Annals of intensive …, 2022 - Springer
Background Post‐intensive care syndrome (PICS) encompasses physical, cognition, and
mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it …

Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections

J Schlechte, AZ Zucoloto, I Yu, CJ Doig, MJ Dunbar… - Nature Medicine, 2023 - nature.com
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …

Advances in the understanding and treatment of sepsis-induced immunosuppression

F Venet, G Monneret - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

[HTML][HTML] Immunomodulatory and antimicrobial effects of vitamin C

S Mousavi, S Bereswill… - European Journal of …, 2019 - akjournals.com
Humans have lost their vitamin C-synthesizing capacities during evolution. Therefore, the
uptake of this essential compound from external sources is mandatory in order to prevent …

[HTML][HTML] The long history of vitamin C: from prevention of the common cold to potential aid in the treatment of COVID-19

G Cerullo, M Negro, M Parimbelli, M Pecoraro… - Frontiers in …, 2020 - frontiersin.org
From Pauling's theories to the present, considerable understanding has been acquired of
both the physiological role of vitamin C and of the impact of vitamin C supplementation on …