Proteogenomic data and resources for pan-cancer analysis

Y Li, Y Dou, FDV Leprevost, Y Geffen, AP Calinawan… - Cancer cell, 2023 - cell.com
Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Quantitative mass spectrometry-based proteomics: an overview

S Rozanova, K Barkovits, M Nikolov, C Schmidt… - Quantitative methods in …, 2021 - Springer
In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

JL Gehrig, S Venkatesh, HW Chang, MC Hibberd… - Science, 2019 - science.org
INTRODUCTION There is a dimension to postnatal human development that involves
assembly of microbial communities in different body habitats, including the gut. Children with …

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

JA Vizcaíno, EW Deutsch, R Wang, A Csordas… - Nature …, 2014 - nature.com
Individual resources can join ProteomeXchange by implementing the ProteomeXchange
data submission and dissemination guidelines, and metadata requirements. In the current …

MS-GF+ makes progress towards a universal database search tool for proteomics

S Kim, PA Pevzner - Nature communications, 2014 - nature.com
Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but
the software tools to analyse tandem mass spectra are lagging behind. We present a …

Proteogenomic characterization of human colon and rectal cancer

B Zhang, J Wang, X Wang, J Zhu, Q Liu, Z Shi… - Nature, 2014 - nature.com
Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Interspecies competition impacts targeted manipulation of human gut bacteria by fiber-derived glycans

ML Patnode, ZW Beller, ND Han, J Cheng, SL Peters… - Cell, 2019 - cell.com
Development of microbiota-directed foods (MDFs) that selectively increase the abundance
of beneficial human gut microbes, and their expressed functions, requires knowledge of both …

Protein analysis by shotgun/bottom-up proteomics

Y Zhang, BR Fonslow, B Shan, MC Baek… - Chemical …, 2013 - ACS Publications
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

[HTML][HTML] Proteogenomic insights suggest druggable pathways in endometrial carcinoma

Y Dou, L Katsnelson, MA Gritsenko, Y Hu, B Reva… - Cancer Cell, 2023 - cell.com
We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors
and 20 enriched normal tissues using 10 different omics platforms. Targeted quantitation of …

Overview and considerations in bottom-up proteomics

RM Miller, LM Smith - Analyst, 2023 - pubs.rsc.org
Proteins are the key biological actors within cells, driving many biological processes integral
to both healthy and diseased states. Understanding the depth of complexity represented …