The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms
The genetic landscape of classical myeloproliferative neoplasm (MPN) is in large part
elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin …
elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin …
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …
complex 2 (PRC2), has attracted broad research attention in the past few years because of …
Chromatin regulatory mechanisms and therapeutic opportunities in cancer
Research over the past several decades has unmasked a major contribution of disrupted
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …
Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia
BJ Wouters, R Delwel - Blood, The Journal of the American …, 2016 - ashpublications.org
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …
Chromatin repressive complexes in stem cells, development, and cancer
A Laugesen, K Helin - Cell stem cell, 2014 - cell.com
The chromatin environment is essential for the correct specification and preservation of cell
identity through modulation and maintenance of transcription patterns. Many chromatin …
identity through modulation and maintenance of transcription patterns. Many chromatin …
[HTML][HTML] Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin
JARID2 is an accessory component of Polycomb repressive complex-2 (PRC2) required for
the differentiation of embryonic stem cells (ESCs). A role for JARID2 in the recruitment of …
the differentiation of embryonic stem cells (ESCs). A role for JARID2 in the recruitment of …
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
Y Shiozawa, L Malcovati, A Gallì, A Sato-Otsubo… - Nature …, 2018 - nature.com
Spliceosome mutations are frequently found in myelodysplasia. Splicing alterations induced
by these mutations, their precise targets, and the effect at the transcript level have not been …
by these mutations, their precise targets, and the effect at the transcript level have not been …
Epigenetic control of adult stem cell function
A Avgustinova, SA Benitah - Nature reviews Molecular cell biology, 2016 - nature.com
Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …
produces a large number of cell types with hugely divergent functions. Distinct cellular …
Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner
Recent studies point to a pivotal role of Polycomb repressive complex 2 (PRC2) in stem cell
function and cancer. Loss-of-function approaches targeting individual PRC2 subunits have …
function and cancer. Loss-of-function approaches targeting individual PRC2 subunits have …