Turning cold tumors hot: from molecular mechanisms to clinical applications
J Zhang, D Huang, PE Saw, E Song - Trends in immunology, 2022 - cell.com
Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …
Hepatocellular carcinoma immune landscape and the potential of immunotherapies
Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …
Predictive biomarkers of colon cancer immunotherapy: Present and future
W Hou, C Yi, H Zhu - Frontiers in immunology, 2022 - frontiersin.org
Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …
Regorafenib plus nivolumab in unresectable hepatocellular carcinoma: the phase 2 RENOBATE trial
Regorafenib has anti-tumor activity in patients with unresectable hepatocellular carcinoma
(uHCC) with potential immunomodulatory effects, suggesting that its combination with …
(uHCC) with potential immunomodulatory effects, suggesting that its combination with …
The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy
The extracellular nucleoside adenosine reduces tissue inflammation and is generated by
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …
Prognostic signatures of sphingolipids: Understanding the immune landscape and predictive role in immunotherapy response and outcomes of hepatocellular …
X Zhang, J Zhuge, J Liu, Z **a, H Wang, Q Gao… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a complex disease with a poor outlook for
patients in advanced stages. Immune cells play an important role in the progression of HCC …
patients in advanced stages. Immune cells play an important role in the progression of HCC …
[HTML][HTML] Exploring markers of exhausted CD8 T cells to predict response to immune checkpoint inhibitor therapy for hepatocellular carcinoma
Background: Reversal of CD8 T-cell exhaustion was considered a major antitumor
mechanism of anti-programmed cell death-1 (PD-1)/anti-programmed death ligand-1 (PD …
mechanism of anti-programmed cell death-1 (PD-1)/anti-programmed death ligand-1 (PD …
[HTML][HTML] Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy
Increasing evidence supports targeting the adenosine pathway in immuno-oncology with
several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and …
several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and …
Case report: persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID
D Goh, JCT Lim, SB Fernaíndez, CR Joseph… - Frontiers in …, 2022 - frontiersin.org
The World Health Organization has defined long COVID-19 (LC) as a condition that occurs
in individuals with a history of SARS-CoV-2 infection who exhibit persistent symptoms after …
in individuals with a history of SARS-CoV-2 infection who exhibit persistent symptoms after …
Full spectrum flow cytometry as a powerful technology for cancer immunotherapy research
DL Bonilla, G Reinin, E Chua - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The Nobel Prize-deserving concept of blocking inhibitory pathways in T cells, to unleash
their anti-tumoral capacity, became one of the pillars of cancer treatment in the last decade …
their anti-tumoral capacity, became one of the pillars of cancer treatment in the last decade …