Advances in large-scale single-unit human neurophysiology, single-cell RNA sequencing,
spatial transcriptomics and long-term ex vivo tissue culture of surgically resected human …

Technological advances enabling massively parallel measurement of biological features—
such as microarrays, high-throughput sequencing and mass spectrometry—have ushered in …

Major aims of single-cell proteomics include increasing the consistency, sensitivity and
depth of protein quantification, especially for proteins and modifications of biological interest …

The development of single-cell multi-omics technology has greatly enhanced our
understanding of biology, and in parallel, numerous algorithms have been proposed to …

Single-cell proteomics sequencing technology sheds light on protein–protein interactions,
posttranslational modifications and proteoform dynamics in the cell. However, the …

Abstract Analysis across a growing number of single-cell perturbation datasets is hampered
by poor data interoperability. To facilitate development and benchmarking of computational …

Background Many biological processes, such as cell division cycle and drug resistance, are
reflected in protein covariation across single cells. This covariation can be quantified and …

The precise control of gene expression is required for the maintenance of cellular
homeostasis and proper cellular function, and the declining control of gene expression with …

Single-cell proteomics by mass spectrometry (MS) allows the quantification of proteins with
high specificity and sensitivity. To increase its throughput, we developed nano-proteomic …

Rescoring of peptide–spectrum matches (PSMs) has emerged as a standard procedure for
the analysis of tandem mass spectrometry data. This emphasizes the need for software …