The alterations of functional connectivity brain networks in major depressive disorder (MDD)
have been subject of a large number of studies. Using different methodologies and focusing …

Irritability is a common and impairing clinical presentation in children and adolescents.
Despite its significant public health impact, irritability remains an elusive construct. Chronic …

Abstract The Research Domain Criteria (RDoC) paradigm was launched 10 years ago as a
superior approach for investigation of mental illness. RDoC conceptualizes normal human …

Objective Alterations in the normal developmental trajectory of amygdala resting state
functional connectivity (rs-FC) have been associated with atypical emotional processes and …

Six years have passed since the National Institute of Mental Health (NIMH) in the United
States launched the Research Domain Criteria (RDoC) initiative. The RDoC introduces a …

Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are
felt, as well as when and how these emotions are experienced or expressed. It is a focal …

Background Patients with bipolar depression are characterized by dysregulation across the
full spectrum of mood, differentiating them from patients with unipolar depression. The ability …

Objective Distinguishing depressive episodes due to bipolar disorder (BD) or major
depressive disorder (MDD) solely on clinical grounds is challenging. We aimed at …

Objective This review discusses the relevance of the National Institute of Mental Health
(NIMH) Research Domain Criteria (RDoC) to clinical research in child and adolescent …

Anxiety symptoms are relatively common during pregnancy and are associated with
behavioural problems in children. The amygdala is involved in emotion regulation, and its …