During the past decades, the mineralocorticoid receptor (MR) has evolved from a much‐
overlooked member of the steroid hormone receptor family to an important player, not only in …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Limitations of current steroidal mineralocorticoid receptor (MR) antagonists have stimulated
the search for a new generation of molecules. We screened for novel nonsteroidal …

Mineralocorticoid receptor (MR) controls sodium homeostasis and blood pressure through
hormone binding and coactivator recruitment. Here, we report a 1.95 Å crystal structure of …

The physiology of mineralocorticoid action, particularly with respect to epithelial sodium
transport, is well defined. A full understanding of the molecular basis of mineralocorticoid …

Pseudohypoaldosteronism (PHA) is a rare heterogeneous syndrome of mineralocorticoid
resistance causing insufficient potassium and hydrogen secretion. PHA type 1 (PHA1) …

The mineralocorticoid receptor (MR), a member of the steroid receptor superfamily,
regulates water-electrolyte balance and mediates pathophysiological effects in the …

Mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) are ligand-dependent
transcription factors. Although it is generally accepted that GR is translocated into the …

Mechanistic aspects of mineralocorticoid receptor activation. Aldosterone exerts its
biological effects through binding to mineralocorticoid receptor (MR). Ligand binding …

Aldosterone plays a key role in electrolyte balance and blood pressure regulation. Type 1
pseudohypoaldosteronism (PHA1) is a primary form of mineralocorticoid resistance …