Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

[HTML][HTML] Curcumin: An epigenetic regulator and its application in cancer

T Ming, Q Tao, S Tang, H Zhao, H Yang, M Liu… - Biomedicine & …, 2022 - Elsevier
Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Targeting histone deacetylases in idiopathic pulmonary fibrosis: a future therapeutic option

M Korfei, P Mahavadi, A Guenther - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment

A Mafi, A Rahmati, Z Babaei Aghdam, R Salami… - Cellular & Molecular …, 2022 - Springer
Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors
have poor 5-year survival for patients. Gliomas are principally characterized by rapid …

Synthesis of bleomycin-inspired RNA ligands targeting the biogenesis of oncogenic miRNAs

C Maucort, M Bonnet, JC Ortuno, G Tucker… - Journal of Medicinal …, 2023 - ACS Publications
Noncoding RNAs (ncRNAs) play pivotal roles in the regulation of gene expression and
represent a promising target for the development of new therapeutic approaches. Among …

Photoresponsive CHA-Integrated Self-Propelling 3D DNA Walking Amplifier within the Concentration Localization Effect of DNA Molecular Framework Enables Highly …

JW He, X Sun, HW Tang, D Liu, CY Li - Analytical Chemistry, 2024 - ACS Publications
While three-dimensional (3D) DNA walking amplifiers hold considerable promise in the
construction of advanced DNA-based fluorescent biosensors for bioimaging, they encounter …

MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

HS Chawra, M Agarwal, A Mishra, SS Chandel… - … -Research and Practice, 2024 - Elsevier
Abstract MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor
biology, with a prominent role in regulating the PTEN tumor suppressor gene and the …

Potential pathogenic impact of cow's milk consumption and bovine milk-derived exosomal MicroRNAs in diffuse large B-Cell lymphoma

BC Melnik, R Stadler, R Weiskirchen… - International Journal of …, 2023 - mdpi.com
Epidemiological evidence supports an association between cow's milk consumption and the
risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma …

Clinical Value of Circulating miRNA in Diagnosis, Prognosis, Screening and Monitoring Therapy of Pancreatic Ductal Adenocarcinoma—A Review of the Literature

J Wnuk, JK Strzelczyk, I Gisterek - International Journal of Molecular …, 2023 - mdpi.com
Pancreatic cancer (PC) is considered to be the seventh most common cause of cancer-
related deaths. The number of deaths caused by PC is estimated to increase in the future …

Advances of multi-omics applications in hepatic precancerous lesions and hepatocellular carcinoma: The role of extracellular vesicles

X Lu, Y Li, Y Li, X Zhang, J Shi, H Feng… - Frontiers in Molecular …, 2023 - frontiersin.org
Due to the lack of distinct early symptoms and specific biomarkers, most patients with
hepatocellular carcinoma (HCC) are usually diagnosed at advanced stages, rendering the …