The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

Growing evidence proposes an important role for pro-inflammatory cytokines during tumor
development. Several experimental and clinical studies have linked the pleiotropic cytokine …

Esophageal cancer (EC) is a disease often marked by aggressive growth and poor
prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant …

Background & Aims One treatment strategy for pancreatic ductal adenocarcinoma is to
modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer …

Macrophages are cells of the innate immune system and represent an important component
of the first-line defense against pathogens and tumor cells. Here, their diverse functions in …

In the past decades, studies of the Janus kinases (JAKs) and signal transducers and
activators of transcription (STATs) signaling have uncovered highly conserved programs …