The term “high-altitude illness” is used to describe the cerebral and pulmonary syndromes
that can develop in unacclimatized persons shortly after ascent to high altitude. Acute …

At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
develo** one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia
inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily …

Several diseases associated with high-altitude exposure affect unacclimated individuals.
These diseases include acute mountain sickness (AMS), high-altitude cerebral edema …

High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Barometric pressure falls with increasing altitude and consequently there is a reduction in
the partial pressure of oxygen resulting in a hypoxic challenge to any individual ascending …

To provide guidance to clinicians about best preventive and therapeutic practices, the
Wilderness Medical Society (WMS) convened an expert panel to develop evidence-based …

Purpose We examined the interaction of various established risk factors for acute mountain
sickness (AMS) in a setting relevant for mountaineering and trekking. Methods …