Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and
lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Abstract Oxidative stress, Nrf2-HO-1 and TLR-MAPK/NF-κB signaling pathways have been
proved to be involved in influenza A virus (IAV) replication and influenzal pneumonia. In the …

Abstract Background Lianhuaqingwen Capsule (LH-C) is a traditional Chinese medicine
(TCM) formula used to treat respiratory tract infectious diseases in Chinese. The aim of this …

SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed
more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly …

Infection with novel SARS-CoV-2 carries significant morbidity and mortality in patients with
pulmonary compromise, such as lung cancer, autoimmune disease, and pneumonia. For …

Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

Abstract Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low
toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the …

A newly diagnosed coronavirus in 2019 (COVID-19) has affected all human activities since
its discovery. Flavonoids commonly found in the human diet have attracted a lot of attention …

Influenza infection and pneumonia are known to cause much of their mortality by inducing
acute respiratory distress syndrome (ARDS), which is the most severe form of acute lung …