Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules
that perform key regulatory functions and drive dynamic complex formation. For decades …

Globular PDZ domains typically serve as protein–protein interaction modules that regulate a
wide variety of cellular functions via recognition of short linear motifs (SLiMs). Often, PDZ …

Small linear motifs targeting protein interacting domains called PSD‐95/Dlg/ZO‐1 (PDZ)
have been identified at the C terminus of the severe acute respiratory syndrome coronavirus …

Human protein networks have been widely explored but most binding affinities remain
unknown, hindering quantitative interactome-function studies. Yet interactomes rely on …

Cellular function is based on protein–protein interactions. A large proportion of these
interactions involves the binding of short linear motifs (SLiMs) by folded globular domains …

Protein-protein interaction motifs are often alterable by post-translational modifications. For
example, 19% of predicted human PDZ domain-binding motifs (PBMs) have been …

The calcium‐binding, vertebrate‐specific S100 protein family consists of 20 paralogs in
humans (referred as the S100ome), with several clinically important members. To explore …

S100 proteins are small, typically homodimeric, vertebrate-specific EF-hand proteins that
establish Ca2+-dependent protein–protein interactions in the intra-and extracellular …

Truncation of the protein-protein interaction SH3 domain of the membrane remodeling
Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here …

Interactomics aims to characterize all interactions formed between molecules that comprise
our body. Although it emerged from quantitative biophysics, it has devolved into a …