Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …

Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation
of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct …

DNA polymerase (pol) β is a small eukaryotic DNA polymerase composed of two domains.
Each domain contributes an enzymatic activity (DNA synthesis and deoxyribose phosphate …

Recent years have seen an explosion in computer power, allowing for the examination of
ever more challenging problems. For instance, a recent simulation study, which was the first …

Nucleoside triphosphates are moldable entities that can easily be functionalized at various
locations. The enzymatic polymerization of these modified triphosphate analogues …

The X family of DNA polymerases in eukaryotic cells consists of terminal transferase, and
DNA polymerases β, λ, and μ. These enzymes have similar structural portraits, yet different …

DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the
genome in all living organisms. dPols catalyze the formation of a phosphodiester bond …

DNA polymerases were named for their function of catalysing DNA replication, a process
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …

The great Chinese strategist Sun Tsu wrote,“So it is said that if you know your enemies and
know yourself, you will fight without danger in battles.” 1 This quote was originally meant to …

Recent years have seen dramatic improvements in computer power, allowing ever more
challenging problems to be approached. In light of this, it is imperative to have a quantitative …