Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …

Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …

Intrinsically disordered proteins can phase separate from the soluble intracellular space,
and tend to aggregate under pathological conditions. The physiological functions and …

DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Although SIRT7 is a member of sirtuin family proteins that are described as NAD+-
dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein …

DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired,
may lead to genomic instability, cell death and senescence. Damage-induced long non …

The ATR replication checkpoint ensures that stalled forks remain stable when replisome
movement is impeded. Using an improved iPOND protocol combined with SILAC mass …

The response to DNA double-strand breaks (DSBs) requires alterations in chromatin
structure to promote the assembly of repair complexes on broken chromosomes. Non …