Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

Alzheimer's disease (AD) is a prevalent and debilitating brain disorder that worsens
progressively with age, characterized by cognitive decline and memory impairment. The …

Background: Neuronal excitotoxicity and metabolic decline, which begin in the early stages
of Alzheimer's disease (AD), pose challenges for effective amelioration. Our previous work …

The unsatisfactory treatment outcome of Alzheimer's disease (AD) can be attributed to two
primary factors, the intricate pathogenic mechanisms leading to restricted treatment …

Ampakines are a class of orally available positive allosteric modulators of the AMPA-
glutamate receptor (AMPAR) and have therapeutic implications for neurological …

Background Use proton magnetic resonance spectroscopy (1H-MRS) non invasive
technique to assess the modifications of glutamate-glutamine (Glx) and gammaaminobutyric …

The complexity of Alzheimer's disease (AD) pathophysiology represents a significant
challenge in the development of effective therapeutic agents for its treatment. CNEURO-201 …

Ampakines, AMPA-type glutamate receptors (AMPAR) positive allosteric modulators,
possess the capacity to treat neurological and neuropsychiatric disorders underpinned by …

Background Metabotropic glutamate receptor 5 (mGluR5) modulates excitatory
glutamatergic synaptic transmission and plays an important role in learning and memory …

To better understand its mechanism of activity towards higher alcohols, we overexpressed
and purified new Geotrichum candidum GDH (Gc GDH). The purified Gc GDH (50.27 kDa) …